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timeless timeless circadian clock [ Danio rerio (zebrafish) ]

Gene ID: 325855, updated on 25-Apr-2024

Summary

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Official Symbol
timelessprovided by ZNC
Official Full Name
timeless circadian clockprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8978
See related
Ensembl:ENSDARG00000078497 AllianceGenome:ZFIN:ZDB-GENE-030131-8978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Tim; fa95g04; fd23d07; im:6903167; wu:fa95g04; wu:fd23d07
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA metabolic process and DNA replication checkpoint signaling. Predicted to act upstream of or within rhythmic process. Predicted to be located in nucleus. Predicted to be part of replication fork protection complex. Orthologous to human TIMELESS (timeless circadian regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (3211847..3249602)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (3143687..3181442)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 21B Neighboring gene copine Vb Neighboring gene microRNA 724 Neighboring gene premelanosome protein a Neighboring gene matrix metallopeptidase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Whitmore D, et al. Nature, 2000 Mar 2. PMID 10716448
  2. Non-Synonymous variants in premelanosome protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma. Lahola-Chomiak AA, et al. Hum Mol Genet, 2019 Apr 15. PMID 30561643, Free PMC Article
  3. Unraveling the mechanisms of the vertebrate circadian clock: zebrafish may light the way. Pando MP, et al. Bioessays, 2002 May. PMID 12001265
  4. The circadian clock of teleost fish: a comparative analysis reveals distinct fates for duplicated genes. Toloza-Villalobos J, et al. J Mol Evol, 2015 Jan. PMID 25487517
  5. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein timeless homolog
Names
timeless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278600.1 → NP_001265529.1  protein timeless homolog

    Status: VALIDATED

    Source sequence(s)
    AL954313
    UniProtKB/TrEMBL
    A0A8M1P001, E7FGL0
    Related
    ENSDARP00000099210.2, ENSDART00000112417.4
    Conserved Domains (2) summary
    pfam05029
    Location:721 → 1275
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25 → 284
    TIMELESS; Timeless protein

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    3211847..3249602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479552.1 → XP_021335227.1  protein timeless homolog isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q1Y3, A0A8M9PUP9
    Related
    ENSDARP00000147782.1, ENSDART00000188786.1
    Conserved Domains (2) summary
    pfam05029
    Location:721 → 1236
    TIMELESS_C; Timeless protein C terminal region
    pfam04821
    Location:25 → 284
    TIMELESS; Timeless protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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